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Diseases & Disorders

Scientists Discover How a Sleeping Cancer Awakens and Metastasizes

Dormant breast & prostate cancer cells that have traveled to the lungs can awaken and metastasize.

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Sleeping cancers can awaken and metastasize. Photo Credit: PDPics/Pixabay
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A new study reveals that cancers in remission are capable of reawakening again. Researchers from the Cold Spring Harbor Laboratory (CSHL) demonstrated how sleeping cancers awaken and metastasize. Based on this knowledge, they developed a treatment plan that can prevent dormant cancer cells from awakening again.

The research was carried out in lab mice with hopes of being tested on humans soon.

According to the researchers, a patient successfully treated and cured of cancer can still become afflicted with the disease again. This is largely because dormant, non-dividing cancer cells that previously detached from an original tumor may move elsewhere to exist in other parts of the body. Once awakened, these dormant cancer cells can multiply and develop into metastatic tumors.

Cancers Become Most Fatal When They Spread Fast To Other Parts of the Body

Metastasis is the spreading of cancer disease from one part of the body to others.

The CSHL team together with scientists from the Dana Farber Cancer Institute and University of California, Davis, found triggers that could reawaken dormant cancer cells. They discovered this while studying metastasis to the lungs.

They found that inflammation of the lungs – caused by tobacco smoking and other factors – can make passive breast and prostate cancer cells which had earlier moved to the lungs to wake up and begin to multiply. The now active cells can grow all over the lungs.

Most common cancers become highly lethal when they metastasize or spread to become active in other parts of the body.

The scientists were however able to block the signals that awakened the dormant cancer cells, demonstrating that cancer progression could be arrested or reversed.

Led by CSHL Associate Professor Mikala Egeblad, the team found that neutrophils awaken surrounding passive cancer cells with lung inflammation caused by tobacco smoke or endotoxin. Neutrophils are common white blood cells, and endotoxin is a bacteria component.

With Successful Trials in Lab Mice, Cured Cancer May Remain in Soon Remain in Remission

Neutrophils destroy bacteria and yeast among other pathogens that invade our bodies. One of the ways they do this is to push out the DNA of the invaders outside of their cell membranes. Armed with toxic enzymes, the expelled DNA creates net-like traps to vanquish pathogens. The net-like trap is known as neutrophil extracellular traps or NETs.

NETs form around dormant cancer cells of patients having prolonged lung inflammation. NETs contains two enzymes known as neutrophil elastase (NE) and matrix metalloproteinase 9 (MMP9). Both NE and MMP9 interact with laminin, a tissue containing protein. NE goes ahead to cut into laminin proteins and MMP9 also does the same. This changes the protein’s shape, exposing a new surface, called an epitope.

When passive cancer cells sense the presence of epitope nearby, they are triggered to begin reawakening and then multiplying. As soon as dormant cancer cells recognize new shapes in the laminin, they are roused from sleep and begin to metastasize.

To prevent dormant cancer cells from rousing, the research team created an antibody that blocks the epitome exposed on the laminin proteins. The scientists have also begun to optimize the antibody to interfere with the activity of NETs, effectively keeping cancer in remission in rats. The researchers hope to begin conducting trials of this study on people soon.

This post was originally published on Health News Office

Liu Kang is an American with Chinese ancestry. She attended University of Maryland where she studied Political Science. She worked on the politics desks of newspapers and later switched to the health desk where she covered health issues. She is married with two kids. She records personal songs in her spare time.

Diseases & Disorders

4 Tips to Create a Healthy Living Space

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You will spend a lot of amount of time in their homes, so it is essential to create a living space that will promote good health and wellbeing. Luckily, there are dozens of ways to detoxify your home environment and create a space that is safe and comfortable. With this in mind, here are four tips for creating a healthy living space: 

1. Maintain a hygienic home

One of the simplest ways to create a healthy home is by keeping your living space clean and hygienic. If you don’t clean your home regularly, then dirt and bacteria will build-up, and this can contribute to various health issues. You can keep your living environment hygienic by following a regular cleaning schedule that includes disinfecting worktops and hoovering to remove dust and dirt. You should also encourage your family to follow good hygiene practices such as washing their hands after using the bathroom and cleaning dirty dishes straight after meals. You can place essential oil hand sanitizer around your home to help kill germs and prevent the spread of illnesses such as the common cold.

2. Use natural cleaning products 

Most store-bought cleaning products contain huge numbers of harsh chemicals that can be damaging to your health and the environment. Fortunately, you can effortlessly make your own natural cleaning products with the help of a few everyday household items. For example, according to experts at positivehealth.com, you can use vinegar in water as an alternative to glass cleaner and baking soda with water as an alternative to oven cleaner. Creating your own cleaning products is much more environmentally friendly, and you won’t risk your family being exposed to potentially harmful toxins. It should also work out far cheaper than purchasing man-made cleaning products. 

3. Keep your household items organized

A cluttered or disorganized living space can create feelings of stress and make it more challenging to complete your household tasks. You should make the effort to keep your living space organized by keeping items stored away when they are not in use. You can easily create additional storage space by purchasing extra storage units. You should also consider having a big clear out and getting rid of any household items you no longer need. There are many different articles offering advice and tips on how to declutter your home and create an organized living space. 

4. Create a dedicated workspace

Advancements in technology mean that large numbers of people now work from home and complete their work tasks remotely. Despite this, many people don’t have a dedicated workspace within their homes. Working from bed or while sitting on the sofa can be harmful to your health and cause problems such as back and neck pain. It can also affect your productivity and make it more challenging to separate your work and personal life. With that in mind, people working from home should create a dedicated workspace that offers quality work equipment such as a desk and ergonomic chair. 

This post was originally published on Health News Office

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Diseases & Disorders

4 Ways to Combine Sports Nutrition with Exercise

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Whether you’re trying to build muscle, lose weight, just be more active or anything in between, finding the balance between diet and exercise is critical. Doing one without the other is useful and a step in the right direction but without combining the two you are unlikely to see the results you want.

Sports nutrition comes in the form of food, drink and supplements. Knowing what to have and when, along with your exercise, is vital to reaching your goals. It is, of course, important to remember that everybody’s body is different, and needs do differ, so there is no one size fits all answer to your required regime.

Muscle building

If you’re looking to build muscle, then protein is the ideal dietary supplement. Protein is what supplies your muscles with essential amino acids that build new tissue, promoting muscle growth. 

There are a number of ways you could introduce more protein to your diet. For example, you could eat more cheese and eggs, as well as carefully looking at what type of meat you consume. High in protein foods that are suitable for vegetarians and vegans are lentils, chickpeas, tofu and almonds amongst many others.

You could also consider consuming bulking protein in shake form, of which there are various flavors. 

Increasing metabolism

Some studies have shown that consuming bee pollen, for instance, can increase your metabolism. Increasing protein intake, drinking more cold water and green tea and eating spicy food are also thought to have this capability.

If it works for you, then finding a way to increase your metabolism can help with weight loss. It isn’t alone in what counts, of course, but it can be effective as your metabolism is your body’s process of making and burning energy from food.

Increasing energy

Eating and drinking products that increase your energy will help you be able to exercise more effectively and for longer. Complex carbohydrates are your usual source of energy, so eating whole-wheat pasta, whole-grain cereals, beans and lentils are all natural ways to boost your workout. 

If you prefer to eat energy bars or use energy gel, then you could obtain them through an online chemist with cheap deals, such as www.chemistdirect.com.au, and have them delivered to your home. 

Rehydration 

During your exercise and once you have finished you should focus on rehydration. You lose fluids while exercising through your sweat and it is important to replace this by drinking enough. One key element that must be restored is your electrolyte – minerals in your body with an electric charge, which help your body perform at its maximum – balance, which can be achieved through drinking the right types of liquid.

To help achieve this, you could use sachets or solutions in water or drink high electrolyte content sports drinks.

Finding the food, drink and products that are right for your body will help you perform to your potential and build the muscle or lose the weight you are looking to. Consulting an expert in diet and exercise is recommended if planning on changing anything too radically. 

This post was originally published on Health News Office

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Diseases & Disorders

3 Types of Common Medical Negligence Claims that Require a Solicitor

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Getting good healthcare is something that no one should have to worry about. One should be able to explicitly trust the physicians and healthcare professionals that they are in the care of and expect to receive a high standard of treatment. 

Unfortunately, though, there are a number of circumstances wherein the occurrence of human error results in a medical negligence case against a healthcare professional. When such situations arise, it is best to enlist the services of a qualified solicitor who has experience in dealing with similar cases.

Here are three of the more common types of medical negligence claims for which you should secure the assistance of a qualified solicitor.

1. Birth Injury

The process of bringing a baby into this world is a complex one. At times, it can also be risky, particularly if you have a pre-existing condition that might cause further complications to arise. At such a volatile and transitional point in your life, the last thing you want to deal with is the occurrence of a birth related injury. 

However, such injuries do happen, and when they do you want to ensure that you have the right solicitor on your side. Solicitors like Diane Rostron have years of experience dealing with such cases and are certainly worth your consideration when you are looking for someone to help you navigate this tricky and legally complex claim.

2. Misdiagnosis

One of the most basic things that physicians are expected to be able to do is present a patient with an accurate and reliable diagnosis. The wrong diagnosis can result in a patient receiving the wrong type of treatment or, worse, no treatment at all. Misdiagnosis claims are more common than one would like to think, with one in six NHS patients reportedly receiving the wrong diagnosis.

While the reasons for a misdiagnosis can depend upon a wide range of factors, the bottom line is that no one should have to suffer the consequences of a misdiagnosis — which can be extreme. Tackling a claim of this nature can be difficult, so make sure the solicitor you use has enough experience with these types of cases.

3. Surgical Negligence

Having to undergo a surgical procedure is not something that most people look forward to. Many experience severe feelings of anxiety when faced with the necessity of having surgery, anxiety that can lead to further mental health issues. The last thing that someone preparing for surgery should have to worry about is the possibility of negligence on the part of the physician.

While it isn’t likely that you will face issues resulting from negligence in your surgery, it is good to know how to find help should the situation arise. Common surgical negligence cases have to do with the wrong procedure being done or the onset of an infection after surgery, resulting from poor hygiene practices. Because the types of surgical negligence cases vary, you should find a solicitor to handle your claim who has specific experience with your type of case. 

This post was originally published on Health News Office

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