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Scientists Discover How a Sleeping Cancer Awakens and Metastasizes

Dormant breast & prostate cancer cells that have traveled to the lungs can awaken and metastasize.

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Sleeping cancers can awaken and metastasize. Photo Credit: PDPics/Pixabay
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A new study reveals that cancers in remission are capable of reawakening again. Researchers from the Cold Spring Harbor Laboratory (CSHL) demonstrated how sleeping cancers awaken and metastasize. Based on this knowledge, they developed a treatment plan that can prevent dormant cancer cells from awakening again.

The research was carried out in lab mice with hopes of being tested on humans soon.

According to the researchers, a patient successfully treated and cured of cancer can still become afflicted with the disease again. This is largely because dormant, non-dividing cancer cells that previously detached from an original tumor may move elsewhere to exist in other parts of the body. Once awakened, these dormant cancer cells can multiply and develop into metastatic tumors.

Cancers Become Most Fatal When They Spread Fast To Other Parts of the Body

Metastasis is the spreading of cancer disease from one part of the body to others.

The CSHL team together with scientists from the Dana Farber Cancer Institute and University of California, Davis, found triggers that could reawaken dormant cancer cells. They discovered this while studying metastasis to the lungs.

They found that inflammation of the lungs – caused by tobacco smoking and other factors – can make passive breast and prostate cancer cells which had earlier moved to the lungs to wake up and begin to multiply. The now active cells can grow all over the lungs.

Most common cancers become highly lethal when they metastasize or spread to become active in other parts of the body.

The scientists were however able to block the signals that awakened the dormant cancer cells, demonstrating that cancer progression could be arrested or reversed.

Led by CSHL Associate Professor Mikala Egeblad, the team found that neutrophils awaken surrounding passive cancer cells with lung inflammation caused by tobacco smoke or endotoxin. Neutrophils are common white blood cells, and endotoxin is a bacteria component.

With Successful Trials in Lab Mice, Cured Cancer May Remain in Soon Remain in Remission

Neutrophils destroy bacteria and yeast among other pathogens that invade our bodies. One of the ways they do this is to push out the DNA of the invaders outside of their cell membranes. Armed with toxic enzymes, the expelled DNA creates net-like traps to vanquish pathogens. The net-like trap is known as neutrophil extracellular traps or NETs.

NETs form around dormant cancer cells of patients having prolonged lung inflammation. NETs contains two enzymes known as neutrophil elastase (NE) and matrix metalloproteinase 9 (MMP9). Both NE and MMP9 interact with laminin, a tissue containing protein. NE goes ahead to cut into laminin proteins and MMP9 also does the same. This changes the protein’s shape, exposing a new surface, called an epitope.

When passive cancer cells sense the presence of epitope nearby, they are triggered to begin reawakening and then multiplying. As soon as dormant cancer cells recognize new shapes in the laminin, they are roused from sleep and begin to metastasize.

To prevent dormant cancer cells from rousing, the research team created an antibody that blocks the epitome exposed on the laminin proteins. The scientists have also begun to optimize the antibody to interfere with the activity of NETs, effectively keeping cancer in remission in rats. The researchers hope to begin conducting trials of this study on people soon.

This post was originally published on Health News Office

Liu Kang is an American with Chinese ancestry. She attended University of Maryland where she studied Political Science. She worked on the politics desks of newspapers and later switched to the health desk where she covered health issues. She is married with two kids. She records personal songs in her spare time.

Diseases & Disorders

Blended Learning Market 2019 – Global Industry Analysis, Size, Share, Growth, Trends And Forecast 2025

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This report includes market status and forecast of global and major regions, with introduction of vendors, regions, product types and end industries; and this report counts product types and end industries in global and major regions.
The report includes as follows:
The report provides current data, historical overview and future forecast.
The report includes an in-depth analysis of the Global market for Blended Learning , covering Global total and major region markets.

Request a sample of this report @ https://www.orbisresearch.com/contacts/request-sample/3861585

The data of 2017-2025 are included. All-inclusive market are given through data on sales, consumption, and prices (Global total and by major regions).
The report provides introduction of leading Global manufacturers.
Blended Learning market prospects to 2025 are included (in sales, consumption and price).

Market Segment as follows:
By Company
Skillsoft
City & Guilds Group
Cegos
D2L
GP Strategies
NIIT

By Region / Countries
North America (U.S., Canada, Mexico)
Europe (Germany, U.K., France, Italy, Russia, Spain etc)
Asia-Pacific (China, India, Japan, Southeast Asia etc)
South America (Brazil, Argentina etc)
Middle East & Africa (Saudi Arabia, South Africa etc)

Make an enquiry of this report @ https://www.orbisresearch.com/contacts/enquiry-before-buying/3861585

By Type
Systems
Content
Courses
Solutions
Others

By End-User / Application
Automotive Industry
BFSI
Consumer Goods Sector
Energy Sector
Others

Table of Contents

1 Market Definition
1.1 Market Segment Overview
1.2 by Type
1.3 by End-Use / Application
2 Global Market by Vendors
2.1 Market Share
2.2 Vendor Profile
2.3 Dynamic of Vendors
3 Global Market by Type
3.1 Market Share
3.2 Introduction of End-Use by Different Products
4 Global Market by End-Use / Application
4.1 Market Share
4.2 Overview of Consumption Characteristics
4.2.1 Preference Driven
4.2.2 Substitutability
4.2.3 Influence by Strategy
4.2.4 Professional Needs
5 Global Market by Regions
5.1 Market Share
5.2 Regional Market Growth
5.2.1 North America
5.2.2 Europe
5.2.3 Asia-Pacific
5.2.4 South America
5.2.5 Middle East & Africa
6 North America Market
6.1 by Type
6.2 by End-Use / Application
6.3 by Regions
7 Europe Market
7.1 by Type
7.2 by End-Use / Application
7.3 by Regions
8 Asia-Pacific Market
8.1 by Type
8.2 by End-Use / Application
8.3 by Regions
9 South America Market
9.1 by Type
9.2 by End-Use / Application
9.3 by Regions
10 Middle East & Africa Market
10.1 by Type
10.2 by End-Use / Application
10.3 by Regions
11 Market Forecast
11.1 Global Market Forecast (2020-2025)
11.2 Market Forecast by Regions (2020-2025)
11.3 Market Forecast by Type (2020-2025)
11.4 Market Forecast by End-Use / Application (2020-2025)
12 Key Manufacturers
12.HubSpot Skillsoft
12.1.2 Company Overview

Continued….

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Diseases & Disorders

According to Latest Report on Artificial Liver Market to Grow with an Impressive CAGR: Top Key Players – Abbott Diabetes Care, Inc. (USA), Baxter International, Inc. (USA), Vital Therapies, Inc, etc.

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Summary of the Report:

Artificial Liver report studies the most recent business trends, market development aspects, market gains, and industry situations throughout the forecast period. The Artificial Liver market report provides the details related to fundamental overview, development status, latest advancements, market dominance, and market dynamics.

Artificial Liver companies need engineering software to develop and fetch the best output. the Artificial Liver is used after exploration has been performed and before production begins in order to best plan how to recover Artificial Liver at optimal cost and the highest level of safety.

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The report presents the market competitive landscape and a corresponding detailed analysis of the major vendor/key players in the market.

This report focuses on top manufacturers covering: Abbott Diabetes Care, Inc. (USA), Baxter International, Inc. (USA), Vital Therapies, Inc. (USA), Xenios AG (Germany), Asahi Kasei Medical Co., Ltd. (Japan), Medtronic, Inc. (USA), F.Hoffmann-La Roche Ltd. (Switzerland), Fresenius Medical Care AG & Co. KGaA (Germany), HeartWare International, Inc. (USA), Jarvik Heart, Inc. (USA), Nikkiso Co., Ltd. (Japan), Nipro Corporation (Japan), SynCardia Systems, Inc. (USA), Terumo Heart, Inc. (USA), Thoratec Corp. (USA), Toray Medical Co., Ltd. (Japan)

On the basis of product, this report displays the Sales, revenue, price, market share and growth rate of each type, primarily split into: Type I, Type II, Type III

By Application, this report focuses on Sales, Market share and Growth Rate of each application, can be divided into: Application 1, Application 2, Application 3

Artificial
Artificial Liver Market

Scope of the Report:

The report is designed to incorporate both qualitative and quantitative aspects of the Artificial Liver Market with respect to each of the regions and countries involved in the study. Furthermore, the report also caters the detailed information about the crucial aspects such as major drivers & restraining factors which will define the future growth of the market. Also covered segments company profile, type, and applications.

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Global Artificial Liver Market Segment by Region:
United States, Europe, China, Japan, Southeast Asia, India, Central & South America

This report focuses on Artificial Liver volume and value at the global level, regional level, and company level. From a global perspective, this report represents the overall Artificial Liver market size by analyzing historical data and future prospects. The report gives a clear understanding of the current market situation which includes the region-wise industry environment, contemporary market and manufacturing trends, leading market contenders, and current consumption tendency of the end-user. The Artificial Liver market report also oversees market size, market share, growth rate, revenue, and CAGR reported previously along with its forecast estimation. Projecting cost-effective and leading fundamentals in the market.

Furthermore, this study will help to solve the following issues:
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 Spotting emerging trends– Report helps to spot upcoming hot market trends. The Report also tracks possible impact and disruptions which a market would witness by a particular emerging trend.
 Interrelated opportunities–This report will allow making decisions based on data, thereby increasing the chances that the strategies will perform better.

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The report could be customized according to the client’s specific research requirements. No additional cost will be required to pay for limited additional research.

This post was originally published on Health News Office

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Diseases & Disorders

Exhaustive Study on Driving Apparel Market 2019 | Strategic Assessment by Top Players: Alpinestars S.p.A. (Italy), Dainese S.p.A. (Italy), Fox Head, etc.

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Driving Apparel Market
Press Release

Driving Apparel Market Analysis:

The objective of the study is to define Industry sizes of different segments & countries in recent years and to forecast the values to the coming years. The report is designed to incorporate both qualitative and quantitative aspects of the industry within each of the regions and countries involved in the study. Furthermore, the report also caters the detailed information about the crucial aspects such as driving factors & challenges which will define the future growth of the Industry. Additionally, the report shall also incorporate available opportunities in micro Industry’s for stakeholders to invest along with the detailed analysis of competitive landscape and product offerings of key players.

The report examines the main players of the Global Driving Apparel Market by investigating their market share, late improvements, new item dispatches, associations, mergers, or acquisitions, and their objective markets. This report additionally incorporates a comprehensive examination of their item profiles to investigate the items and applications their activities are focused on in the Global Driving Apparel Market. Furthermore, the report gives two unmistakable market estimates, one from the point of view of the maker and another from that of the customer. It offers profitable suggestions for new just as built up players of the Global Driving Apparel Market.

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Competitive Landscape of the Driving Apparel Industry:

The report offers the detailed competitor profiles of some of the key market players, covering product launches, key developments, financials figures, product sales, and gross margin, short-term and long-term marketing strategies adopted by them, and SWOT analysis. Many market players are taking efforts to make new product innovations and expand their geographical footprint in the upcoming years.

Top manufactures include for Driving Apparel market such as: Alpinestars S.p.A. (Italy), Dainese S.p.A. (Italy), Fox Head, Inc. (U.S.), Scott Sports SA (Switzerland), ThorMX (U.S.), PUMA SE, Adidas AG

Types of Driving Apparel covered are: Clothing, Footwear, Protection Gear

Applications of Driving Apparel covered are: Two Wheeler, Four Wheeler, Others

Driving Apparel Market

Driving Apparel Market

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Target Audiences of This Report:

• Analysts and Strategic Business Planners
• Driving Apparel Manufacturers, Suppliers and Distributors
• Government Regulatory and Research Organizations
• Venture Capitalists and Private Equity Firms
• Investment Research Firms / Associations
• End-Use Industries

The Global Driving Apparel Market is well characterized in (15) chapters:

-Chapter 1 provides an overall market review, market share, growth prospects, product specialization related to global Driving Apparel market;
-Chapter 2 compares the cost structure of the key players, as well as the usage of raw materials with sales, financial status, and price analysis of the overall market;
-Chapter 3 provides a brief about the sales structure as well as the profit earned by the leading market players in emerging regions over the forecast period;
-Chapter 4 presents the regional analysis of Global Driving Apparel market along with the income and sales structure in each region over the forecast period;
-Chapter 5, 6, 7 provides an in-depth analysis of the key countries such as United States, China, Germany, Japan, and Korea, along with their sales and revenues share in the Driving Apparel market;
-Chapter 8 and 9 evaluates the overall market by product type and end-user applications such as market share, sales structure and growth rate;
-Chapter 10 and 11 provides market forecast by region, type and application with revenue and sales from 2019 to 2025;
-Chapter 13, 14 and 15 unveils the different methodologies used to gather information, approaches used in the research findings, Appendix, Conclusion, sales channels, and various data sources.

Read Detailed Index of full Research Study at: https://www.acquiremarketresearch.com/industry-reports/driving-apparel-market/222936/

The growth of this market globally is subjected to various factors, including consumer ace Driving Apparel of a lot of Driving Apparel products, inorganic company growth models, price volatility of raw materials, product innovation along with economic prospects in both producer and consumer countries.

Conclusively, This report will provide you a clear view of each and every facet of the market without a need to refer to any other research report or a data source. Our report will provide you with all the facet about the past, present, and future of the concerned Market.

This post was originally published on Health News Office

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